52-Week Top Gaining U.S. stocks

Track U.S. stocks with the strongest price gains over the past 52 weeks on MEXC. Stocks are ranked by their 52-week percentage change to highlight leading one-year performers.

Market Overview

U.S. stocks are broadly lower today, with the Dow Jones down ⁦0.30%⁩, the S&P 500 down ⁦0.37%⁩, and the Nasdaq Composite down ⁦0.73%⁩. Market breadth is negative, with 3,487 stocks declining versus 1,623 advancing, pointing to a broadly bearish bias.

Dow Jones

52,231.59

Change

-158.16-0.30%

S&P 500

7,522.27

Change

-27.67-0.37%

Nasdaq Composite

25,069.785

Change

-183.354-0.73%

24H Gainers

1,623

24H Losers

3,487

52 Week Gainers

Large Cap Small Cap 52 Week Gainers 52 Week Losers Semiconductor Software Biotech Bank

#	Stock					52 Week Range
4951	Vistagen Therapeutics, Inc.VTGN	$0.18	-0.54%	524.40K	$8.17M	$0.16 - $5.14	0.00%
4952	Aspire-Lakewood Holdings, Inc.ASBP	$8.51	+3.85%	5.42K	$11.93M	$3.31 - $372.00	0.00%
4953	Core AI Holdings, Inc.CHAI	$0.16	-4.97%	177.89K	$3.19M	$0.16 - $4.05	0.00%
4954	FiscalNote Holdings, Inc.NOTE	$0.00	0.00%	0	$0	$0.00 - $3.28	0.00%
4955	America's Car Mart Inc.CRMT	$0.88	-23.03%	345.80K	$7.31M	$0.57 - $28.70	0.00%
4956	Agroz Inc.AGRZ	$1.99	-9.36%	6.84K	$2.09M	$1.73 - $105.68	0.00%
4957	Arcadia Biosciences, Inc.RKDA	$0.16	-5.88%	176.31K	$385.47K	$0.11 - $3.87	0.00%
4958	Microvast Holdings, Inc.MVST	$0.22	-63.90%	35.25M	$84.90M	$0.21 - $5.30	0.00%
4959	Veraxa Biotech AGVRXA	$1.09	+8.91%	161.57K	$134.34M	$0.90 - $27.36	0.00%
4960	Tenon Medical, Inc.TNON	$1.75	+5.71%	97.49K	$4.72M	$1.57 - $45.50	0.00%
4961	Boxlight CorporationBOXL	$1.85	-3.89%	4.45K	$1.57M	$1.70 - $48.24	0.00%
4962	Rich Sparkle Holdings LimitedANPA	$1.26	+3.33%	15.75K	$17.97M	$1.14 - $180.64	0.00%
4963	Getty Images Holdings, Inc.GETY	$0.08	-40.95%	27.99M	$0	$0.00 - $3.21	0.00%
4964	Aptevo Therapeutics Inc.APVO	$1.09	-4.04%	40.59K	$1.98M	$1.07 - $28.08	0.00%
4965	Algorhythm Holdings, Inc.RIME	$0.08	-7.08%	1.08M	$1.36M	$0.08 - $4.58	0.00%
4966	YYForce Inc.YFOR	$0.05	-42.23%	18.23M	$430.24K	$0.05 - $2.05	0.00%
4967	Tempest Therapeutics, Inc.TPST	$0.38	-0.69%	273.75K	$7.52M	$0.34 - $10.33	0.00%
4968	Dogness (International) CorporationDOGZ	$0.46	+2.90%	24.40K	$3.95M	$0.33 - $13.00	0.00%
4969	GRI Bio, Inc.GRI	$1.86	+9.36%	55.47K	$4.06M	$1.36 - $64.12	0.00%
4970	Nocera, Inc.NCRA	$1.44	-10.20%	5.62K	$3.59M	$1.29 - $39.90	0.00%
4971	3 E Network Technology Group LtdMASK	$1.99	-4.88%	22.61K	$2.60M	$1.50 - $66.53	0.00%
4972	Artelo Biosciences, Inc.ARTL	$2.15	+0.94%	92.71K	$1.18M	$1.91 - $179.19	0.00%
4973	Cloudastructure, Inc.CSAI	$1.62	-7.95%	26.21K	$1.39M	$1.50 - $48.60	0.16%
4974	Powell Max LimitedPMAX	$0.81	+0.94%	80.71K	$1.06M	$0.45 - $33.50	0.00%
4975	HUHUTECH International Group Inc.HUHU	$0.38	+6.52%	26.66M	$9.61M	$0.25 - $12.20	0.00%
4976	Solmate Infrastructure Public Limited CompanySLMT	$2.98	+1.02%	27.98K	$24.99M	$2.70 - $84.00	0.00%
4977	Datavault AI Inc.DVLT	$0.06	+2.83%	36.93M	$60.23M	$0.05 - $2.70	0.00%
4978	VS Media Holdings LimitedVSME	$1.03	+28.05%	219.32K	$4.69M	$0.58 - $30.80	0.00%
4979	Maison Solutions Inc.MSS	$0.94	-8.62%	147.13K	$761.91K	$0.84 - $29.00	0.00%
4980	Trident Digital Tech Holdings LtdTDTH	$0.76	-2.70%	2.86K	$21.87M	$0.56 - $21.00	0.00%
4981	IceCure Medical Ltd.ICCM	$0.78	-3.94%	170.46K	$2.67M	$0.65 - $22.50	0.00%
4982	Nexalin Technology, Inc.NXL	$1.44	-1.64%	21.07K	$1.54M	$1.31 - $40.80	0.00%
4983	EyePoint, Inc.EYPT	$0.40	+11.27%	3.61M	$34.83M	$0.33 - $19.11	0.00%
4984	Innventure, Inc.INV	$0.15	-2.56%	1.76M	$12.24M	$0.12 - $7.86	0.00%
4985	Vivos Therapeutics, Inc.VVOS	$0.09	-7.93%	522.72K	$2.95M	$0.09 - $2.72	0.00%
4986	VenHub Global, Inc.VHUB	$0.22	-9.65%	133.96K	$21.66M	$0.21 - $40.30	0.00%
4987	Future FinTech Group Inc.FTFT	$3.24	+4.03%	115.62K	$28.11M	$1.22 - $97.27	0.00%
4988	Moleculin Biotech, Inc.MBRX	$8.18	-3.23%	20.44K	$8.87M	$3.23 - $253.05	0.00%
4989	707 Cayman Holdings LimitedJEM	$2.42	-2.65%	5.07K	$1.60M	$2.21 - $135.24	0.00%
4990	Triller Group Inc.ILLR	$0.19	-18.65%	3.40M	$0	$0.01 - $7.96	0.00%
4991	MDxHealth SAMDXH	$0.14	-9.69%	1.53M	$14.98M	$0.14 - $4.63	0.00%
4992	Pop Culture Group Co., LtdCPOP	$3.04	+5.00%	8.64K	$2.86M	$2.47 - $382.50	0.00%
4993	Cango Inc.CANG	$1.12	+2.70%	337.17K	$40.79M	$0.88 - $37.30	0.00%
4994	BGM Group LtdBGM	$8.34	+0.37%	794	$105.83M	$6.45 - $291.30	0.00%
4995	reAlpha Tech Corp.AIRE	$0.38	-0.25%	145.12K	$2.32M	$0.32 - $16.20	0.00%
4996	Cable One, Inc.CABO	$3.76	-13.77%	300.50K	$21.32M	$3.76 - $138.00	0.00%
4997	Decent Holding Inc.DXST	$0.83	-1.34%	11.13K	$2.39M	$0.81 - $62.00	0.00%
4998	iSpecimen Inc.ISPC	$0.73	-8.19%	66.66K	$1.83M	$0.71 - $27.44	0.00%
4999	INVO Fertility, Inc.IVF	$2.47	+5.96%	30.40K	$2.55M	$1.59 - $98.00	0.00%
5000	Nuvve Holding Corp.NVVE	$3.26	-41.80%	11.49M	$0	$0.54 - $464.40	0.00%

BTC $81K: Catch the Next Move

Track ETH, SOL & TON rotation signals

Trade U.S. stocks Your Way on MEXC

	RealStocks	Tokenized Stocks	Stock Futures
What it is	RealStocks — real shares of U.S.-listed companies	Blockchain-based tokens linked to U.S. stocks/ETFs	USDT-margined futures on U.S. stock price movements
Ownership	Yes — actual shares	No — synthetic exposure only	No — derivative exposure only
Shareholder rights	Yes (e.g. dividends)	No	No
Trading hours	U.S. market sessions (pre-market, regular, after-hours, overnight)	24/7	Up to 24/7 (supported pairs)
Position types	Buy and hold	Buy and hold	Long, short, leveraged
Best for	Long-term investors seeking ownership and dividend income	Traders wanting round-the-clock access to stock exposure without holding shares	Active/short-term traders looking to speculate or hedge with leverage

Why Trade U.S. stocks on MEXC?

RealStocks, Real Ownership

Buy real US-listed shares through MEXC's partner licensed broker and receive applicable shareholder benefits, including dividends.

7,000+ U.S. stocks & ETFs

Access 7,000+ US-listed stocks and ETFs across technology, finance, healthcare, consumer sectors, and more.

Seamless USDT-to-Stock Access

Transfer USDT and convert between USDT and USD to fund your RealStocks account with ease.

Lower-Cost Stock Trading

Trade real U.S. stocks with competitive costs and keep more capital available for your investment strategy.

Frequently Asked Questions (FAQ)

What are 52-week top gaining U.S. stocks?

These are U.S. stocks with some of the strongest price gains over the past 52 weeks, providing a view of longer-term stock performance.

How is the 52-week gain calculated?

It compares a stock's latest available price with its price roughly 52 weeks earlier and expresses the change as a percentage.

Which stock has gained the most over 52 weeks?

Vistagen Therapeutics, Inc. (VTGN) currently leads with a 52-week gain of 95.38% as of 2026-11-11 00:52 UTC.

Why use a 52-week stock performance ranking?

It helps users identify stocks with sustained price strength over a longer period rather than focusing only on daily market moves.

Does strong 52-week performance guarantee future gains?

No. Historical stock performance does not determine future returns and should be considered alongside company fundamentals and current market conditions.

How is this different from the daily Top Gainers list?

The 52-week ranking focuses on one-year performance, while Top Gainers highlights shorter-term price movements.

Discover Top US Stocks

Disclaimer

US stock prices, indices, rankings, charts, and other market data displayed on this page may be sourced from third-party providers and may be delayed or inaccurate. MEXC provides this information for informational and educational purposes only and does not guarantee its accuracy or completeness. Nothing on this page constitutes financial or investment advice or a recommendation to buy or sell any security. US stock trading involves risk, and past performance does not guarantee future results. Users should conduct independent research before making investment decisions.