Buy Crypto
Markets
Spot
FuturesBTC
Earn
Event Center
Rewards Hub
More
100%+ PoR

52-Week Top Gaining U.S. stocks

Track U.S. stocks with the strongest price gains over the past 52 weeks on MEXC. Stocks are ranked by their 52-week percentage change to highlight leading one-year performers.

52-Week Top Gaining U.S. stocks

Market Overview

U.S. stocks are broadly lower today, with the Dow Jones down ⁦0.30%⁩, the S&P 500 down ⁦0.38%⁩, and the Nasdaq Composite down ⁦0.74%⁩. Market breadth is negative, with 3,480 stocks declining versus 1,630 advancing, pointing to a broadly bearish bias.

Dow Jones
52,231.89
Change
-157.86-0.30%
S&P 500
7,520.93
Change
-29.01-0.38%
Nasdaq Composite
25,065.874
Change
-187.265-0.74%
24H Gainers
1,630
24H Losers
3,480

52 Week Gainers

#Stock52 Week Range
4201Hyperion DeFi, Inc.HYPD$2.57-1.94%156.80K$40.00M$2.34 - $6.300.02%
4202JELD-WEN Holding, Inc.JELD$1.01-12.17%818.06K$88.08M$0.93 - $3.270.00%
4203HawkEye 360, Inc.HAWK$14.98-0.60%855.80K$1.45B$11.25 - $35.730.00%
4204BuzzFeed, Inc.BZFD$0.46-15.47%437.01K$38.49M$0.46 - $2.210.00%
4205Eagle Nuclear Energy Corp.NUCL$3.80-2.31%196.45K$122.30M$3.53 - $14.220.00%
4206SiNtx Technologies, Inc.SINT$1.56+2.60%10.60K$11.83M$1.40 - $4.460.00%
4207BitMine Immersion Technologies, Inc.BMNR$18.07-2.53%27.88M$10.90B$12.80 - $43.770.00%
4208Grande Group LimitedGRAN$1.16+3.12%7.21K$26.98M$0.78 - $5.910.00%
4209Clene Inc.CLNN$4.43+1.14%142.01K$63.79M$3.02 - $10.840.00%
4210AGNT, Inc.AGNT$2.89-9.95%2.39M$476.52M$2.89 - $7.060.06%
4211Synlogic, Inc.SYBX$0.000.00%0$0$0.54 - $1.860.00%
4212FitLife Brands, Inc.FTLF$8.13-0.18%9.52K$76.30M$7.66 - $19.500.00%
4213Digi Power X Inc.DGXX$2.15-3.57%2.76M$218.51M$1.77 - $9.200.00%
4214CLEANSPARK INC.CLSK$6.57-4.92%14.21M$1.69B$5.53 - $19.170.02%
4215Mobileye Global Inc.MBLY$5.64-3.92%4.72M$1.42B$4.89 - $14.330.00%
4216Annovis Bio, Inc.ANVS$0.87-6.59%1.62M$37.39M$0.62 - $5.500.00%
4217MiMedx Group, Inc.MDXG$3.37+1.20%851.32K$491.19M$3.02 - $7.770.00%
4218NeOnc Technologies Holdings, Inc.NTHI$4.43+18.72%379.58K$115.96M$2.50 - $12.000.00%
4219Janux Therapeutics, Inc.JANX$12.04-5.72%2.21M$736.27M$11.58 - $35.340.00%
4220Humacyte, Inc.HUMA$0.59+25.90%15.26M$163.07M$0.34 - $1.520.00%
4221MIRA Pharmaceuticals, Inc.MIRA$0.63+1.91%46.18K$26.60M$0.51 - $1.690.00%
4222KEY Tronic Corp.KTCC$1.28-2.61%33.50K$14.16M$1.25 - $4.420.00%
4223Gain Therapeutics, Inc.GANX$1.08-2.00%402.92K$47.05M$0.94 - $4.340.00%
4224Black Rock Coffee Bar, Inc.BRCB$10.56-4.91%564.84K$238.51M$6.11 - $25.270.00%
4225Mesa Royalty TrustMTR$1.91+0.17%1.80K$3.55M$1.85 - $5.830.00%
4226Fidelity National Information Services, Inc.FIS$28.29+0.04%7.82M$14.58B$27.93 - $68.370.06%
4227CoinShares PLCCSHR$3.72-1.72%116.32K$498.13M$3.50 - $10.430.00%
4228Lucky Strike Entertainment CorporationLUCK$3.42-8.24%217.51K$276.77M$3.32 - $9.590.07%
4229comScore, Inc.SCOR$3.12-7.42%55.22K$47.38M$3.05 - $9.340.00%
4230Instil Bio, Inc.TIL$6.39-0.50%21.00K$43.32M$5.56 - $16.000.00%
4231AEVEX Corp.AVEX$11.61+0.35%1.13M$705.82M$8.95 - $42.340.00%
4232Atlantic American Corp.AAME$1.25+13.27%137.41K$25.44M$1.01 - $3.240.04%
4233Foghorn Therapeutics Inc.FHTX$1.90-7.35%660.71K$112.65M$1.79 - $7.610.00%
4234IZEA Worldwide, Inc.IZEA$2.18-1.34%35.66K$37.76M$2.13 - $5.500.00%
4235International Money Express, Inc.IMXI$6.50-14.13%1.06M$196.41M$6.47 - $15.950.00%
4236Voyager Therapeutics, Inc.VYGR$1.82-8.04%597.66K$113.57M$1.68 - $5.480.00%
4237Nerdy Inc.NRDY$5.79-16.91%23.74K$52.95M$5.37 - $22.350.00%
4238Ribbon Communications Inc.RBBN$1.40-2.78%409.11K$249.95M$1.28 - $3.410.00%
4239Zevia PBCZVIA$1.11-14.84%1.16M$80.12M$1.08 - $2.780.00%
4240KinderCare Learning Companies, Inc.KLC$2.21-5.15%684.80K$262.52M$1.63 - $5.760.00%
4241Lite Strategy, Inc.LITS$0.96+1.63%270.11K$29.19M$0.69 - $2.260.00%
4242National CineMedia, Inc.NCMI$1.66-0.60%691.52K$155.30M$1.43 - $4.330.08%
4243Stran & Company, Inc.SWAG$1.30+1.41%13.06K$24.19M$1.21 - $3.500.00%
4244ZOOZ Strategy Ltd.ZOOZ$5.41-2.54%5.83K$42.88M$4.55 - $13.450.00%
4245Snail, Inc.SNAL$2.14+3.08%15.09K$6.87M$1.70 - $10.800.00%
4246Cytosorbents Corp.CTSO$6.09+4.95%9.02K$19.18M$2.84 - $17.000.00%
4247Universe Pharmaceuticals Inc.UPC$1.55-2.20%12.74K$875.99K$1.33 - $17.960.00%
4248ERock, Inc.EROC$7.88-4.61%1.41M$343.00M$6.41 - $20.700.00%
4249Telomir Pharmaceuticals, Inc.TELO$0.57-16.96%429.26K$42.36M$0.54 - $1.580.00%
4250Figma, Inc.FIG$18.62-4.15%10.81M$10.08B$16.60 - $45.420.00%

BTC $81K: Catch the Next Move

Track ETH, SOL & TON rotation signals

BTC $81K: Catch the Next Move

Trade U.S. stocks Your Way on MEXC

RealStocksTokenized StocksStock Futures
What it isRealStocks — real shares of U.S.-listed companiesBlockchain-based tokens linked to U.S. stocks/ETFsUSDT-margined futures on U.S. stock price movements
OwnershipYes — actual sharesNo — synthetic exposure onlyNo — derivative exposure only
Shareholder rightsYes (e.g. dividends)NoNo
Trading hoursU.S. market sessions (pre-market, regular, after-hours, overnight)24/7Up to 24/7 (supported pairs)
Position typesBuy and holdBuy and holdLong, short, leveraged
Best forLong-term investors seeking ownership and dividend incomeTraders wanting round-the-clock access to stock exposure without holding sharesActive/short-term traders looking to speculate or hedge with leverage

Why Trade U.S. stocks on MEXC?

RealStocks, Real Ownership

Buy real US-listed shares through MEXC's partner licensed broker and receive applicable shareholder benefits, including dividends.

7,000+ U.S. stocks & ETFs

Access 7,000+ US-listed stocks and ETFs across technology, finance, healthcare, consumer sectors, and more.

Seamless USDT-to-Stock Access

Transfer USDT and convert between USDT and USD to fund your RealStocks account with ease.

Lower-Cost Stock Trading

Trade real U.S. stocks with competitive costs and keep more capital available for your investment strategy.

Frequently Asked Questions (FAQ)

What are 52-week top gaining U.S. stocks?
These are U.S. stocks with some of the strongest price gains over the past 52 weeks, providing a view of longer-term stock performance.
How is the 52-week gain calculated?
It compares a stock's latest available price with its price roughly 52 weeks earlier and expresses the change as a percentage.
Which stock has gained the most over 52 weeks?
Hyperion DeFi, Inc. (HYPD) currently leads with a 52-week gain of 55.77% as of 2026-11-11 02:00 UTC.
Why use a 52-week stock performance ranking?
It helps users identify stocks with sustained price strength over a longer period rather than focusing only on daily market moves.
Does strong 52-week performance guarantee future gains?
No. Historical stock performance does not determine future returns and should be considered alongside company fundamentals and current market conditions.
How is this different from the daily Top Gainers list?
The 52-week ranking focuses on one-year performance, while Top Gainers highlights shorter-term price movements.

Discover Top US Stocks

Disclaimer

US stock prices, indices, rankings, charts, and other market data displayed on this page may be sourced from third-party providers and may be delayed or inaccurate. MEXC provides this information for informational and educational purposes only and does not guarantee its accuracy or completeness. Nothing on this page constitutes financial or investment advice or a recommendation to buy or sell any security. US stock trading involves risk, and past performance does not guarantee future results. Users should conduct independent research before making investment decisions.