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52-Week Top Gaining U.S. stocks

Track U.S. stocks with the strongest price gains over the past 52 weeks on MEXC. Stocks are ranked by their 52-week percentage change to highlight leading one-year performers.

52-Week Top Gaining U.S. stocks

Market Overview

U.S. stocks are broadly lower today, with the Dow Jones down ⁦0.30%⁩, the S&P 500 down ⁦0.38%⁩, and the Nasdaq Composite down ⁦0.74%⁩. Market breadth is negative, with 3,486 stocks declining versus 1,624 advancing, pointing to a broadly bearish bias.

Dow Jones
52,231.89
Change
-157.86-0.30%
S&P 500
7,520.93
Change
-29.01-0.38%
Nasdaq Composite
25,065.874
Change
-187.265-0.74%
24H Gainers
1,624
24H Losers
3,486

52 Week Gainers

#Stock52 Week Range
4701Vestand Inc.VSTD$0.10-44.44%2.05M$0$0.00 - $0.730.00%
4702Niki BioSolutions, Inc.NIKI$1.59-4.57%29.92K$1.29M$1.42 - $12.240.00%
4703PN Smart Energy LimitedPN$2.33-0.85%13.85K$34.97M$1.77 - $40.000.00%
4704The Generation Essentials GroupTGE$0.25-29.17%1.73M$17.62M$0.22 - $1.900.00%
4705ZenaTech, Inc.ZENA$0.70+5.13%1.08M$141.01M$0.58 - $5.170.00%
4706Scienture Holdings, Inc.SCNX$3.07-4.38%5.75K$5.42M$2.64 - $19.470.00%
4707Ensysce Biosciences, Inc.ENSC$0.36-3.35%127.30K$7.04M$0.23 - $2.170.00%
4708Hadron Energy, Inc.HDRN$0.71+2.42%53.99K$51.12M$0.60 - $5.400.00%
4709LENZ Therapeutics, Inc.LENZ$4.09-4.55%820.09K$128.67M$2.80 - $32.130.00%
4710BeneficientBENF$0.69+2.36%125.19K$13.18M$0.50 - $9.960.00%
4711Anavex Life SciencesAVXL$1.14-6.97%488.15K$105.21M$1.06 - $7.600.00%
4712MetaVia Inc.MTVA$1.53-6.21%102.21K$7.93M$0.97 - $13.420.00%
4713Galaxy Payroll Group LimitedGLXG$0.69-0.25%36.42K$5.18M$0.53 - $4.790.00%
4714BridgeBio Oncology Therapeutics, Inc.BBOT$2.19-4.35%394.18K$163.56M$1.98 - $14.870.00%
4715Defi Technologies, Inc.DEFT$0.30-9.68%2.96M$118.05M$0.30 - $1.790.00%
4716CISO Global, Inc.CISO$0.17-1.30%506.91K$7.93M$0.15 - $1.040.00%
4717Nvni Group LimitedNVNI$0.53-34.28%518.40K$5.32M$0.51 - $4.940.00%
4718Ainos, Inc.AIMD$0.48-15.68%57.50K$3.56M$0.46 - $3.880.00%
4719Fusemachines Inc.FUSE$0.34-2.86%34.55K$10.82M$0.22 - $3.670.00%
4720Greenland Mines LtdGRML$3.99-4.56%374.75K$54.66M$2.82 - $27.480.00%
4721Atossa Therapeutics, Inc.ATOS$2.15+1.88%53.58K$21.41M$1.70 - $14.850.00%
4722Conexeu Sciences Inc.CNXU$2.22-5.58%202.13K$69.68M$2.02 - $18.790.00%
4723TScan Therapeutics, Inc.TCRX$0.18+3.25%565.82K$11.75M$0.17 - $1.470.00%
4724loanDepot, Inc.LDI$0.48-9.52%3.87M$111.22M$0.46 - $3.240.00%
4725Thryv Holdings, Inc.THRY$1.07-16.80%1.80M$47.55M$0.93 - $6.600.00%
4726Opendoor Technologies Inc.OPEN$1.30-7.45%43.95M$1.26B$1.27 - $9.150.00%
4727Sono Group N.V.SSM$0.96+3.78%213.47K$3.57M$0.85 - $10.540.00%
4728Expion Energy, Inc.XPON$2.55-3.04%9.21K$2.58M$2.26 - $19.200.00%
4729Amesite Inc.AMST$0.51-11.27%66.77K$3.31M$0.47 - $3.050.00%
4730PRF Technologies Ltd.PRFX$0.78-6.51%20.32K$2.38M$0.64 - $7.950.00%
4731Nyxoah SANYXH$0.90-2.13%98.60K$86.12M$0.80 - $5.920.00%
4732The OLB Group, Inc.OLB$0.17-2.04%345.89K$5.46M$0.16 - $1.800.00%
4733Barfresh Food Group Inc.BRFH$0.50-7.65%29.71K$8.17M$0.42 - $3.500.00%
4734FuboTV Inc.FUBO$7.84-2.06%825.58K$236.83M$7.44 - $48.240.00%
4735Neumora Therapeutics, Inc.NMRA$0.47-3.58%659.72K$87.37M$0.32 - $3.650.00%
4736BioNexus Gene Lab Corp.BGLC$0.87-3.13%1.91K$2.54M$0.82 - $5.410.00%
4737Anebulo Pharmaceuticals, Inc.ANEB$0.000.00%0$0$0.00 - $2.490.00%
4738IQSTEL INC.IQST$0.78-2.38%84.38K$8.56M$0.73 - $5.170.00%
4739Presidio Property Trust, Inc.SQFT$0.84+5.11%722$1.21M$0.72 - $5.441.16%
4740Greenland Energy CompanyGLND$2.14-8.19%971.06K$104.52M$1.09 - $23.000.00%
4741Maris-Tech Ltd.MTEK$0.26-4.98%130.49K$2.56M$0.21 - $2.820.00%
4742Dominari Holdings Inc.DOMH$0.81-30.43%698.66K$19.61M$0.74 - $5.710.70%
4743PAVmed Inc.PAVM$1.63-9.82%9.76K$13.03M$1.35 - $28.440.00%
4744NOMADAR Corp.NOMA$1.02-5.56%8.58K$20.45M$1.01 - $10.000.00%
4745American Vanguard CorporationAVD$0.82+0.36%622.22K$24.13M$0.81 - $5.550.00%
4746DEFSEC Technologies Inc.DFSC$0.53-2.26%30.44K$2.43M$0.49 - $5.090.00%
4747Arbor Realty Trust, Inc.ABR$1.47-8.13%5.45M$270.19M$1.46 - $9.460.80%
4748Gemini Space Station, Inc.GEMI$2.65-2.39%1.61M$322.34M$2.31 - $17.230.00%
4749OIO GroupOIO$1.81-0.56%101.84K$629.92M$1.36 - $11.550.00%
4750Context Therapeutics Inc.CNTX$0.19-5.94%612.85K$17.27M$0.18 - $3.620.00%

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Frequently Asked Questions (FAQ)

What are 52-week top gaining U.S. stocks?
These are U.S. stocks with some of the strongest price gains over the past 52 weeks, providing a view of longer-term stock performance.
How is the 52-week gain calculated?
It compares a stock's latest available price with its price roughly 52 weeks earlier and expresses the change as a percentage.
Which stock has gained the most over 52 weeks?
Vestand Inc. (VSTD) currently leads with a 52-week gain of 81.93% as of 2026-11-11 01:13 UTC.
Why use a 52-week stock performance ranking?
It helps users identify stocks with sustained price strength over a longer period rather than focusing only on daily market moves.
Does strong 52-week performance guarantee future gains?
No. Historical stock performance does not determine future returns and should be considered alongside company fundamentals and current market conditions.
How is this different from the daily Top Gainers list?
The 52-week ranking focuses on one-year performance, while Top Gainers highlights shorter-term price movements.

Discover Top US Stocks

Disclaimer

US stock prices, indices, rankings, charts, and other market data displayed on this page may be sourced from third-party providers and may be delayed or inaccurate. MEXC provides this information for informational and educational purposes only and does not guarantee its accuracy or completeness. Nothing on this page constitutes financial or investment advice or a recommendation to buy or sell any security. US stock trading involves risk, and past performance does not guarantee future results. Users should conduct independent research before making investment decisions.