52-Week Top Losing U.S. stocks

Track U.S. stocks with the largest price declines over the past 52 weeks on MEXC. Stocks are ranked by 52-week percentage change from lowest to highest.

Market Overview

U.S. stocks are broadly lower today, with the Dow Jones down ⁦0.30%⁩, the S&P 500 down ⁦0.38%⁩, and the Nasdaq Composite down ⁦0.74%⁩. Market breadth is negative, with 3,485 stocks declining versus 1,625 advancing, pointing to a broadly bearish bias.

Dow Jones

52,231.89

Change

-157.86-0.30%

S&P 500

7,520.93

Change

-29.01-0.38%

Nasdaq Composite

25,065.874

Change

-187.265-0.74%

24H Gainers

1,625

24H Losers

3,485

52 Week Losers

Large Cap Small Cap 52 Week Gainers 52 Week Losers Semiconductor Software Biotech Bank

#	Stock					52 Week Range
451	Anavex Life SciencesAVXL	$1.14	-6.97%	488.15K	$105.21M	$1.06 - $7.60	0.00%
452	BeneficientBENF	$0.69	+2.36%	125.19K	$13.18M	$0.50 - $9.96	0.00%
453	LENZ Therapeutics, Inc.LENZ	$4.09	-4.55%	820.09K	$128.67M	$2.80 - $32.13	0.00%
454	Hadron Energy, Inc.HDRN	$0.71	+2.42%	53.99K	$51.12M	$0.60 - $5.40	0.00%
455	Ensysce Biosciences, Inc.ENSC	$0.36	-3.35%	127.30K	$7.04M	$0.23 - $2.17	0.00%
456	Scienture Holdings, Inc.SCNX	$3.07	-4.38%	5.75K	$5.42M	$2.64 - $19.47	0.00%
457	ZenaTech, Inc.ZENA	$0.70	+5.13%	1.08M	$141.01M	$0.58 - $5.17	0.00%
458	The Generation Essentials GroupTGE	$0.25	-30.56%	1.73M	$17.62M	$0.22 - $1.90	0.00%
459	PN Smart Energy LimitedPN	$2.33	-0.85%	13.85K	$34.97M	$1.77 - $40.00	0.00%
460	Niki BioSolutions, Inc.NIKI	$1.59	-4.57%	29.92K	$1.29M	$1.42 - $12.24	0.00%
461	LASE Corp.LASE	$0.58	-3.46%	519.53K	$29.10M	$0.38 - $4.49	0.00%
462	Vestand Inc.VSTD	$0.10	-44.44%	2.05M	$0	$0.00 - $0.73	0.00%
463	Eightco Holdings Inc.ORBS	$0.72	-1.57%	7.10M	$300.72M	$0.57 - $4.67	0.00%
464	Elicio Therapeutics, Inc.ELTX	$1.61	-2.13%	177.21K	$45.52M	$1.25 - $16.00	0.00%
465	Avax One Technology LtdAVX	$4.03	-0.96%	145.75K	$29.83M	$2.81 - $31.80	0.00%
466	NuScale Power CorporationSMR	$5.22	-3.57%	33.64M	$2.14B	$4.28 - $32.09	0.00%
467	Ucommune International LtdUK	$1.61	+0.62%	1.45K	$1.07M	$1.39 - $10.50	0.00%
468	DarioHealth Corp.DRIO	$2.40	+19.66%	53.70K	$23.47M	$1.78 - $14.77	0.00%
469	Creative Medical Technology Holdings, Inc.CELZ	$0.60	-1.00%	32.98K	$3.98M	$0.59 - $4.72	0.00%
470	Corteva, Inc.CTVA	$12.17	+0.50%	8.59M	$8.12B	$11.24 - $90.97	0.06%
471	Incannex Healthcare LimitedIXHL	$2.02	-7.76%	180.07K	$25.40M	$1.97 - $14.91	0.00%
472	SunCar Technology Group Inc.SDA	$0.36	-18.18%	6.46M	$21.34M	$0.13 - $2.45	0.00%
473	MacKenzie Realty Capital, Inc.MKZR	$0.93	-5.00%	1.72K	$2.58M	$0.83 - $5.22	0.00%
474	NeuroOne Medical Technologies CorporationNMTC	$0.80	-11.88%	135.27K	$7.27M	$0.76 - $6.12	0.00%
475	SANGRIX INC.SGRX	$0.40	-12.33%	300.05K	$1.59M	$0.30 - $3.44	0.00%
476	Odyssey Marine Exploration, Inc.OMEX	$10.36	-4.19%	10.94K	$24.32M	$9.59 - $66.75	0.00%
477	Upexi, Inc.UPXI	$0.63	-4.64%	960.83K	$55.82M	$0.54 - $3.65	0.00%
478	Freightos LimitedCRGO	$0.76	+7.91%	92.25K	$39.80M	$0.58 - $4.24	0.00%
479	Xtend AI Robotics, Inc.XTND	$1.18	+3.98%	2.08M	$248.43M	$0.80 - $7.15	0.00%
480	BOXABL, Inc.BXBL	$1.87	-0.53%	102.75K	$466.20M	$1.76 - $11.99	0.00%
481	Aptera Motors Corp.SEV	$1.61	-29.39%	1.50M	$86.37M	$1.29 - $8.80	0.00%
482	Loop Industries, Inc.LOOP	$0.25	+11.96%	47.49K	$12.15M	$0.24 - $1.54	0.00%
483	ThredUp Inc.TDUP	$1.49	+9.16%	1.59M	$167.48M	$1.24 - $8.76	0.00%
484	Psyence Biomedical LtdPBM	$2.99	-0.43%	25.78K	$11.39M	$1.92 - $18.62	0.00%
485	Bone Biologics Corp.BBLG	$0.33	-4.00%	31.11K	$1.13M	$0.32 - $2.39	0.00%
486	Cerenome, Inc.CNSY	$0.68	+19.16%	1.11M	$5.19M	$0.43 - $4.25	0.00%
487	Compass Therapeutics, Inc.CMPX	$0.83	+0.30%	1.89M	$150.19M	$0.67 - $6.88	0.00%
488	Prairie Operating CoPROP	$0.36	-0.86%	594.64K	$41.17M	$0.32 - $2.55	0.00%
489	Cogent Communications Holdings, Inc.CCOI	$4.34	-2.36%	1.65M	$222.53M	$3.56 - $28.70	0.27%
490	TEN Holdings, Inc.XHLD	$0.85	-1.64%	1.75M	$6.97M	$0.38 - $15.43	0.00%
491	Caribou Biosciences, Inc.CRBU	$0.41	-4.69%	1.51M	$44.19M	$0.39 - $2.49	0.00%
492	Guardforce AI Co., LimitedGFAI	$0.17	-4.79%	46.65K	$5.53M	$0.17 - $0.98	0.00%
493	Intelligent Group LimitedINTJ	$2.22	-9.06%	9.04K	$5.24M	$2.17 - $12.52	0.00%
494	Nakamoto Inc.NAKA	$5.86	-2.06%	75.77K	$107.46M	$3.33 - $32.04	0.00%
495	Terrestrial Energy Inc.IMSR	$2.73	-9.17%	2.50M	$301.01M	$2.44 - $14.29	0.00%
496	Bakkt, Inc.BKKT	$4.17	-10.11%	1.22M	$66.38M	$3.86 - $25.00	0.00%
497	CollPlant Biotechnologies LtdCLGN	$3.90	-7.23%	22.03K	$7.38M	$2.64 - $22.50	0.00%
498	Alset Inc.AEI	$0.49	+1.43%	4.24K	$18.98M	$0.47 - $3.98	0.00%
499	CervoMed Inc.CRVO	$1.38	-3.50%	185.80K	$20.85M	$1.27 - $10.00	0.00%
500	Polestar Automotive Holding UK PLCPSNY	$4.61	-2.33%	101.22K	$752.08M	$3.22 - $24.40	0.00%

1
•••
8
9
10
11
12
•••
104

BTC $81K: Catch the Next Move

Track ETH, SOL & TON rotation signals

Trade U.S. stocks Your Way on MEXC

	RealStocks	Tokenized Stocks	Stock Futures
What it is	RealStocks — real shares of U.S.-listed companies	Blockchain-based tokens linked to U.S. stocks/ETFs	USDT-margined futures on U.S. stock price movements
Ownership	Yes — actual shares	No — synthetic exposure only	No — derivative exposure only
Shareholder rights	Yes (e.g. dividends)	No	No
Trading hours	U.S. market sessions (pre-market, regular, after-hours, overnight)	24/7	Up to 24/7 (supported pairs)
Position types	Buy and hold	Buy and hold	Long, short, leveraged
Best for	Long-term investors seeking ownership and dividend income	Traders wanting round-the-clock access to stock exposure without holding shares	Active/short-term traders looking to speculate or hedge with leverage

Why Trade U.S. stocks on MEXC?

RealStocks, Real Ownership

Buy real US-listed shares through MEXC's partner licensed broker and receive applicable shareholder benefits, including dividends.

7,000+ U.S. stocks & ETFs

Access 7,000+ US-listed stocks and ETFs across technology, finance, healthcare, consumer sectors, and more.

Seamless USDT-to-Stock Access

Transfer USDT and convert between USDT and USD to fund your RealStocks account with ease.

Lower-Cost Stock Trading

Trade real U.S. stocks with competitive costs and keep more capital available for your investment strategy.

Frequently Asked Questions (FAQ)

What are 52-week top losing U.S. stocks?

These are U.S. stocks that have recorded some of the largest price declines over the past 52 weeks.

How is the 52-week decline measured?

It compares the latest available stock price with its price around 52 weeks earlier and calculates the percentage change.

Which stock has fallen the most over 52 weeks?

Anavex Life Sciences (AVXL) currently shows a 52-week decline of 82.51% as of 2026-11-11 01:06 UTC.

Why track 52-week stock losers?

The ranking helps identify stocks facing prolonged price weakness and provides a starting point for further company and valuation research.

Is a 52-week loser automatically a value stock?

No. A lower stock price does not necessarily mean a company is undervalued, so valuation and fundamental data should be reviewed separately.

How is this different from Top Losers?

52-Week Losers measures longer-term performance, while Top Losers focuses on shorter-term market declines.

Discover Top US Stocks

Disclaimer

US stock prices, indices, rankings, charts, and other market data displayed on this page may be sourced from third-party providers and may be delayed or inaccurate. MEXC provides this information for informational and educational purposes only and does not guarantee its accuracy or completeness. Nothing on this page constitutes financial or investment advice or a recommendation to buy or sell any security. US stock trading involves risk, and past performance does not guarantee future results. Users should conduct independent research before making investment decisions.